Homocysteine altered gyrification related to self‐awareness of everyday cognition

Background Previous studies on homocysteine have verified higher may adversely influence cognition performance in individuals with subjective cognitive decline (SCD), whereas the potential mechanisms for this relationship are still unclear. Method We analyzed data from 23 SCD enrolled 500 nm light therapy cohort who filled 12 items Everyday Cognition scale (ECog-12) and had plasma levels assessed at time of their baseline 3T MRI scans. Gyrification cortical thickness were obtained by using whole brain region interest (ROI)-based approach CAT12 toolbox (in SPM12). Statistical analyses used one-sample t-test including age sex as covariates. Regions significant group effects regions analyses. Result At corrected thresholds (p < 0.05, Holm-Bonferroni-corrected), there negative correlations between gyrification left temporal pole = 0.012000) right inferior sulcus 0.012268). For thickness, we found a positive correlation 0.032744). In addition, was self-report ECog-12 scores pole. Conclusion Homocysteine alters local surface shape lobule patients localized low imply impaired self-awareness everyday cognition.